Journal article
Molecular imaging of activated platelets via antibody-targeted ultra-small iron oxide nanoparticles displaying unique dual MRI contrast
HT Ta, Z Li, CE Hagemeyer, G Cowin, S Zhang, J Palasubramaniam, K Alt, X Wang, K Peter, AK Whittaker
Biomaterials | ELSEVIER SCI LTD | Published : 2017
Abstract
Magnetic resonance imaging (MRI) is a powerful and indispensable tool in medical research, clinical diagnosis, and patient care due to its high spatial resolution and non-limited penetration depth. The simultaneous use of positive and negative MRI imaging that employs the same contrast agents will significantly improve detection accuracy. Here we report the development of functional multimodal iron oxide nanoparticles for targeted MRI of atherothrombosis using a combination of chemical and biological conjugation techniques. Monodisperse, water-soluble and biocompatible ultra-small magnetic dual contrast iron oxide nanoparticles (DCIONs) were generated using a high-temperature co-precipitatio..
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Awarded by Australian National Fabrication Facility
Funding Acknowledgements
This work is funded by National Health and Medical Research Council (H.T.T: APP1037310), University of Queensland Early Career Grant (H.T.T.: UQECR1606713), the Australian Research Council (A.K.W.: CE140100036, K.P.: FT0992210), the National Heart Foundation (C.E.H: CR 11M6066, X.W: 100517), and the National Natural Science Foundation of China (Z.L.: 81471657 and 81527901). The authors would like to acknowledge the Australian National Fabrication Facility (Queensland Node); National Imaging Facility, Centre for Advanced Imaging for access to key items of equipment. The authors would also like to acknowledge Dr Barbara Rolfe for some advices on the project.